When will a Dictator be Good?

When will resistance be futile?

Cancer cells rapidly evolve a multitude of defense mechanisms to evade the effects of the oncologist's drug arsenal. Unfortunately, clinical strategies to overcome these lag far behind. This mismatch likely underlies our inability to implement new durable treatment strategies. Here, a new form of multidrug resistance, inducible drug glucuronidation, is discussed. This form was discovered while ...

When Will Information Retrieval Be “Good Enough”? User Effectiveness As a Function of Retrieval Accuracy

We describe a user study that examined the relationship between the quality of an Information Retrieval system and the effectiveness of its users in performing a task. The task involves finding answer facets of questions pertaining to a collection of newswire documents over a six month period. We artificially created sets of ranked lists at increasing levels of quality by blending the output of...

When a good fit can be bad.

How should we select among computational models of cognition? Although it is commonplace to measure how well each model fits the data, this is insufficient. Good fits can be misleading because they can result from properties of the model that have nothing to do with it being a close approximation to the cognitive process of interest (e.g. overfitting). Selection methods are introduced that fact...

Strategies of vaccine production against COVID-19: when will an effective vaccine be produced?

There is a strong consensus globally that production of an effective vaccine against SARS-CoV-2 is likely the most effective approach to sustainably controlling the COVID-19 pandemic. An unprecedented research effort and global coordination has resulted in a rapid development of vaccine candidates and initiation of trials. In this paper, we review vaccine candidate against COVID-19 and also cha...

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